1. to get angry, to get mad, to lose one's temper, to fly into a rage, to blow one's top
2. to go straight to one's head (of alcohol), to feel the effects (of an illness), to lose one's wits
1. thing, matter
2. incident, occurrence, event, something serious, trouble, crisis
3. circumstances, situation, state of affairs
4. work, business, affair
5. after an inflectable word, creates a noun phrase indicating something the speaker does not ...